A Solution-Phase Combinatorial Parallel Synthesis of 3β-Amido-3α-hydroxy-5α-androstane-17-ones. -A two-level library of title compounds (IV) is prepared via reaction of oxirane (I) with 4 primary amines followed by treatment of each set with 4 aliphatic acyl chlorides. The purities of the products
✦ LIBER ✦
The synthesis of 123m Te-labeled 17β -hydroxy-2-tellura-A-nor-5α-androstane
✍ Scribed by F. F. Knapp Jr
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 451 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
Abstract
A microscale synthesis has been developed for the preparation of 17β‐hydroxy‐2‐tellura‐A‐nor‐5α‐androstane. Reactorproduced ^123m^Te has been used to prepare the ^123m^Te labeled steroid. The radiochemical synthesis and purification of this potential prostate imaging agent are described in detail.
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## Abstract The spirostanic side chain of pennogenin (I) can be quantitatively transformed under mild acidic conditions in a 22‐oxocholestanic framework through a one‐step procedure.