✦ LIBER ✦

The synthesis and use of [14C]carbon monoxide in Pd-catalyzed carbonylation reactions

✍ Scribed by Charles S. Elmore

Publisher: John Wiley and Sons
Year: 2010
Tongue: French
Weight: 178 KB
Volume: 54
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1809

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✦ Synopsis

Abstract

The [^14^C]carbonylation reaction is a very powerful method of incorporating C‐14 into a drug molecule late in a radiochemical synthesis. The first and perhaps most critical step in [^14^C]carbonylation reactions is the generation of ^14^CO and its subsequent delivery to the reaction flask. There are three published methods for generating ^14^CO: conversion of ^14^CO~2~ with Zn at 400°C, pyrolysis of Ca^14^CO~3,~ and dehydration of NaOCH. Additionally, a newly published method for the in situ carbonylation of aryl and vinyl halides to give acids has been investigated using NaOCH as the labeled precursor. Finally, the application of ^14^CO in Pd‐catalyzed [^14^C]carbonylation reactions will be discussed. Copyright © 2010 John Wiley & Sons, Ltd.

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