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The synthesis and stereoselective conjugate addition reactions of α-alkoxyorganocuprate reagents

✍ Scribed by Russell J Linderman; Alex Godfrey

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
214 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

a-Alkoxystannane J-was prepared by the method by Still.la Transmetallation with nBuLi in THF at -78'C and addition of the lithio anion to a solution of cyclohexenone produced the unstable 1,2-addition product 2. -GC analysis of the crude product mixture indicated that no 1,4-addition had occurred. Conditions for the reproducible formation the cuprate were then developed. The cuprate reagent formed quite readily, as noted by the absence of 2 in the reaction with cyclohexenone; however, -the yields of 1,4-addition t OMOM CHO

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