The synthesis and nucleophilic substitution of haloxanthones

✍ Scribed by Hashem Sharghi; Fatemeh Tamaddon

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2001
• Tongue: English
• Weight: 60 KB
• Volume: 38
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570380311

✦ Synopsis

Abstract

Acylation reaction of m‐cresol with 2,6‐dihalobenzoic acid in the presence of methansulfonic acid and subsequently, cyclization of the obtained o‐hydroxybenzophenones with K~2~CO~3~/dimethyl formamide, afforded haloxanthones 4 and 5 in high yields. Aromatic nucleophilic substitution of the resulted haloxanthones with O‐, N‐ and S‐nucleophiles are studied in a comparative manner, and various new O‐, N‐ and S‐substituted xanthones have obtained.