The synthesis and secretion of the toxic exoprotein e-haemolysin of E. coli PM152 is coded by the transmissible plasmid pHly152 (41 x 10 6 dalton) as shown by the transformation of the plasmid DNA and the isolation of mutants that are specifically altered in the synthesis and transport of haemolysin
The synthesis and function of the Escherichia coli hemolysin and related RTX exotoxins
β Scribed by R.A. Welch; C. Forestier; A. Lobo; S. Pellett; W. Thomas Jr.; G. Rowe
- Book ID
- 109318013
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 580 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0378-1097
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A sequence (hlyR) of about 600 bp which enhances the expression of hemolysin (HlyA) more than 50-fold was identified in the plasmid pHly152-specific hemolysin (hly) determinant. Deletion of this entire hlyR sequence led to the same low level of hemolysin synthesis and excretion as that expressed by
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