The synthesis and enzymatic polymerization of 5-thio-and 5-methylmercurithio-pyrimidine nucleotides
β Scribed by D.C. Livingston; R.M.K. Dale; D.C. Ward
- Book ID
- 115746474
- Publisher
- Elsevier Science
- Year
- 1976
- Weight
- 716 KB
- Volume
- 454
- Category
- Article
- ISSN
- 0005-2787
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ABSTRAm 5,6-Anhydro-1,2-0-isopropylidene-3-O-methanesulphonyl-a-~-idofuranose was converted, via the related gZucod$-episulphide, into 6-0-acetyl-5-S-acetyl-1,2-O-isopropylidene-3-O-methanesulphonyl-5-thio-at-D-glucofuranose (9). Replacement of the acetyl groups of 9, or the related 3-toluene-p-sulp
1,2,3,4-Tetra-0-acetyl-5-thio-D-xylopyranose (1) reacts with the silylated lumazine bases (2-s) under trimgthylsilyl trifliioromethylsulfonate catalysis to give the nucleoSides f& 8, 10, and 12 respectively, which face deblocking with potassium carbonate iii dFy methanol to yield the free nucleoside