✦ LIBER ✦
The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor
✍ Scribed by Yongchun Hou; Xuejun Wu; Wenhua Xie; Paul G Braunschweiger; Peng G Wang
- Book ID
- 104211652
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 104 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-nitroso-N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5-and 26-fold increased cytotoxicity was observed compared to glucose-2-SNAP and SNAP against DU-145 human prostate cancer cells in vitro.