The synthesis and characterization of new polymerizable pyrimidines: Immobilization of the monomers onto hydrophilic graft copolymeric supports through radiation-induced copolymerization–grafting

✍ Scribed by S. Pegiadou; J. T. Guthrie; M. H. Gill

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 176 KB
• Volume: 70
• Category: Article
• ISSN: 0021-8995
• DOI: 10.1002/(sici)1097-4628(19981010)70:2<211::aid-app1>3.0.co;2-x

✦ Synopsis

Polymerizable quaternary allyl-pyrimidinium salts, that is, 1-allyl-4amino-5-phenyl-pyrimidine (IV), 1-allyl-4-acetamido-5-phenyl-pyrimidine (V), 1-allyl-5-hydroxymethylamino-5-phenyl-pyrimidine (VI), and 1-allyl-pyrimidine (VIII) bromides, as well as 4-acrylamido-5-phenyl-pyrimidines IIЈ and IVЈ, were synthesized and characterized. Three of the activated pyrimidine derivatives, the two acrylamido and one allyl pyrimidine, were immobilized onto (Agar-g-co-HEMA)-X-TMPTA via graft copolymerization. Each copolymer system, based on 2-hydroxyethyl methacrylate (HEMA) grafted onto Agar followed by crosslinking with trimethyllopropane triacrylate (TMPTA), was prepared by radiation-induced copolymerization carried out in the simultaneous mode. The release properties of the immobilized pyrimidines were assessed in various aqueous media over a period of approximately 22 days.