Difluoromethylation of Amines with Zn(CF
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S. V. Pasenok; N. V. Kirij; Yu. L. Yagupolskii; D. Naumann; W. Tyrra; A. Fitzner
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Article
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1999
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John Wiley and Sons
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German
β 93 KB
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The reactions of Zn(CF 3 )Br Β΄2 CH 3 CN, Cd(CF 3 ) 2 Β΄2 CH 3 CN or Bi(CF 3 ) 3 /AlCl 3 with tertiary amines lead to the formation of quaternary ammonium salts of the general formula [R 3 NCF 2 H]X. The reaction of 4-N,N-dimethylaminopyridine with Zn(CF 3 )Br Β΄2 CH 3 CN yields (Ndifluoromethyl)-4-N,N