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The synthesis and biological evaluation of A-ring substituted steroidal p-quinones

✍ Scribed by Dragana R. Milić; Miroslav J. Gašić; Wolfgang Muster; János J. Csanádi; Bogdan A. Šolaja

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
695 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

The preparation of A-ring steroidal 1,4-quinones involves m-CPBA / (BzO)20 / hv oxidation of estrone (or estradiol 17-acetate), acid rearrangement of the obtained quinol, and oxidation. A detailed NMR analysis of 1,4-quinones and their derivatives, as well as the results of preliminary antibacterial and cytotoxicity tests is presented.

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