Syntheses and GABA receptor binding prop
Syntheses and GABA receptor binding properties of 4-amino-1-, 2-, and 3-hydroxybutylphosphinic acids
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Jan Kehler; Bjarke Ebert; Otto Dahl; Povl Krogsgaard-Larsen
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Article
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1999
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Elsevier Science
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French
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Novel racemic 4-amino-l-, 2-, and 3-hydroxybutylphosphinic acids and the corresponding 4-amino-1-, 2-, and 3-hydroxybutyl methylphosphinic acids have been synthesized. The phosphinic acid groups are bioisosteres of the carboxylic acid group, and some of these hydroxy amino acids are GABAB antagonist