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The synergistic effect of bone mineral density and methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) on fractures

✍ Scribed by Masataka Shiraki; Tomohiko Urano; Tatsuhiko Kuroda; Mitsuru Saito; Shiro Tanaka; Mariko Miyao-Koshizuka; Satoshi Inoue


Publisher
Springer
Year
2008
Tongue
English
Weight
264 KB
Volume
26
Category
Article
ISSN
0914-8779

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Effect of methylenetetrahydrofolate redu
✍ Giuseppe Toffoli; Antonio Russo; Federico Innocenti; Giuseppe Corona; Salvatore πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 French βš– 93 KB

## Abstract MTHFR is a critical enzyme that regulates the metabolism of folate and methionine, both of which are important factors in DNA methylation and synthesis. Subjects with the 677C→T variant have impaired remethylation of Hcy to methionine that could determine hyperhomocysteinemia. Remethyla