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The synapsins and the regulation of synaptic function

✍ Scribed by Martin Bähler; Fabio Benfenati; Flavia Valtorta; Paul Greengard

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
680 KB
Volume
12
Category
Article
ISSN
0265-9247

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✦ Synopsis

Synapsins I and I1 are a family of synaptic vesicleassociated phosphoproteins involved in the short-term regulation of neurotransmitter release. In this review, we discuss a working model for the molecular mechanisms by which the synapsins act. We propose that synapsin I links synaptic vesicles to actin filaments in the presynaptic nerve terminal and that these interactions are modulated by the reversible phosphorylation of synapsin I through various signal transduction pathways. The high degree of homology between the synapsins suggests that some of the functional properties of synapsin I are also shared by synapsin 11.

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