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The Syk tyrosine kinase: A new negative regulator in tumor growth and progression

โœ Scribed by Peter J. Coopman; Susette C. Mueller

Book ID
116334040
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
195 KB
Volume
241
Category
Article
ISSN
0304-3835

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โœ Jing Li; Neil Sidell ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 355 KB

Syk, a nonreceptor type of protein tyrosine kinase widely expressed in hematopoietic cells, is a candidate suppressor gene in human breast cancer. Reduced expression of Syk protein is correlated with poor prognosis, while its overexpression can reduce the malignant phenotype of breast cancer cells.