✦ LIBER ✦
The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence
✍ Scribed by Heike Helmbold; Umberto Galderisi; Wolfgang Bohn
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 182 KB
- Volume
- 227
- Category
- Article
- ISSN
- 0021-9541
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Cellular senescence is a response to genotoxic stress that results in an irreversible cell cycle arrest. Activation of this pathway relies on the activity of the retinoblastoma proteins and proteins of the DNA damage response cascade. Here, we discuss the functional relevance of the switch from pRb/p105 to Rb2/p130 that becomes apparent when cells enter senescent arrest. J. Cell. Physiol. 227: 508–513, 2012. © 2011 Wiley Periodicals, Inc.