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The SWI/SNF chromatin remodeling subunit BRG1 is a critical regulator of p53 necessary for proliferation of malignant cells

✍ Scribed by Naidu, S R; Love, I M; Imbalzano, A N; Grossman, S R; Androphy, E J


Book ID
109970920
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
472 KB
Volume
28
Category
Article
ISSN
0950-9232

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Brg1, the ATPase subunit of the SWI/SNF
✍ Diana Vradii; Stefan Wagner; Diem N. Doan; Jeffrey A. Nickerson; Martin Montecin 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 406 KB

## Abstract Many mammalian SWI/SNF complexes use Brahma‐related gene 1 (Brg1) as a catalytic subunit to remodel nucleosomes for transcription regulation. In several mesenchymal cells and tissues, expression of a defective Brg1 protein negates the normal activity of the SWI/SNF complex and delays or