The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD

Brg1, the ATPase subunit of the SWI/SNF

Brg1, the ATPase subunit of the SWI/SNF chromatin remodeling complex, is required for myeloid differentiation to granulocytes

✍ Diana Vradii; Stefan Wagner; Diem N. Doan; Jeffrey A. Nickerson; Martin Montecin 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 406 KB

## Abstract Many mammalian SWI/SNF complexes use Brahma‐related gene 1 (Brg1) as a catalytic subunit to remodel nucleosomes for transcription regulation. In several mesenchymal cells and tissues, expression of a defective Brg1 protein negates the normal activity of the SWI/SNF complex and delays or