The surface structure of murine ascites tumors. II. Difference in cytotoxicity of various phytoagglutinins toward yoshida sarcoma cells in vitro
✍ Scribed by Motowo Tomita; Tsutoma Kurokawa; Kikuo Onozaki; Toshiaki Osawa; Yoshio Sakurai; Tyunosin Ukita
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- French
- Weight
- 375 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Several phytoagglutinins having different sugar specificities were found to exert different agglutinating activity toward murine ascites cell lines. It was also found that some of these phytoagglutinins, especially.
Ricinus communis.
and.
Abrus precatorius.
agglutinins, inhibited the growth of Yoshida sarcoma (YS) cells and showed a strong cytotoxic effect. This kind of cytotoxicity of.
Ricinus communis.
agglutinin, which is specific for galactose, was shown to be counteracted by the addition of galactose but not of glucose, and this fact indicated that the cytotoxicity of the phytoagglutinin is related to the binding specificity of the agglutinin toward the sugar chains on the cell surface. On the other hand, in some phytoagglutinins, the cytotoxicity was found to be relatively low even when their agglutinating activity was remarkably high. On the basis of these results, the role of the sugar chains on cell surface in cellular functions is discussed.