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The suppressed proliferation and premature senescence by ganciclovir in p53-mutated human non-small-lung cancer cells acquiring herpes simplex virus-thymidine kinase cDNA

โœ Scribed by C.-C. Chiu; C.-H. Li; T.-S. Fuh; W.-L. Chen; C.-S. Huang; L.-J. Chen; W.H. Ung; K. Fang


Book ID
113524286
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
383 KB
Volume
29
Category
Article
ISSN
0361-090X

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Human non-small cell lung cancer (NSCLC) cells were transfected with recombinant prodrug herpes simplex virus type I thymidine kinase (HSV-tk) cDNA, and the selected clones underwent apoptosis in response to induction by antiviral ganciclovir (GCV). The efficiency of GCV-induced growth inhibition an