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The study of mechanisms of new drugs: Potential toxicity using genomic, proteomic and metabolomic tools

✍ Scribed by N. Fabre; I. Anglade; J. Barr; M. Betanzos; M. Conde; L. Osaba; Joan Albert Vericat

Book ID: 119380954
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 52 KB
Volume: 189
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2009.06.062

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## Abstract Metabolic activation of drug candidates to electrophilic reactive metabolites that can covalently modify cellular macromolecules may result in acute and/or idiosyncratic immune system‐mediated toxicities in humans. This presents a significant potential liability for the future developme