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The study of aberrant methylation in cancer via restriction landmark genomic scanning

✍ Scribed by Smiraglia, Dominic J; Plass, Christoph


Book ID
110066786
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
251 KB
Volume
21
Category
Article
ISSN
0950-9232

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Aberrant methylation of the CDKN2a/p16IN
✍ Aude Lamy; Richard SesboΓΌΓ©; Jeannette Bourguignon; Brigitte DautrΓ©aux; Josette M πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 French βš– 97 KB

## Abstract Among the identified factors involved in malignant transformation, abnormal methylation of the __CDKN2A/p16__^__INK4a__^ gene promoter has been described as an early event, particularly in bronchial cell cancerization. Precancerous bronchial lesions (__n__ = 70) prospectively sampled du