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The structures of the unique sulfotransferase retinol dehydratase with product and inhibitors provide insight into enzyme mechanism and inhibition

✍ Scribed by Svetlana Pakhomova; Jochen Buck; Marcia E. Newcomer


Book ID
119824391
Publisher
Cold Spring Harbor Laboratory Press
Year
2009
Tongue
English
Weight
454 KB
Volume
14
Category
Article
ISSN
0961-8368

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✍ Lei Jin; Boguslaw Stec; William N. Lipscomb; Evan R. Kantrowitz πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 529 KB

A high-resolution structure of Escherichia coli aspartate transcarbamoylase has been determined to 2.1 Γ…; resolution in the presence of the bisubstrate analog N-phosphonacetyl-L-aspartate (PALA). The structure was refined to a free R-factor of 23.4% and a working R-factor of 20.3%. The PALA molecule