The structure of the olivomycin-chromomycin antibiotics
โ Scribed by Yu.A. Berlin; S.E. Esipov; M.N. Kolosov; M.M. Shemyakin
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- French
- Weight
- 201 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0040-4039
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The structure of the chromophore chromomyclnone was deduced as Indicated in the following scheme. Chromomrcin A3 1 CH3COOH, boil 2 hrs Chromomvcinone (CHR) UV same as chromomycin A5 :. Chromophore still intact. Chromomycinone No.34 m.p. 183-135', having a typical naphthoquinone UV spectrum, A",izH 2
The chromomycins are a group of cancerostatic antibiotics produced by Streptomyces griseus 1) and are undoubtedly closely related to olivomycin 2) and several other antibiotics 3, isolated by various groups. 4) The principal constituent, chromomycin A3@) is commercially available , while chromomyci