Structure-function relationship of immun
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Laurence A. Turka; Craig B. Thompson
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Article
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1991
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John Wiley and Sons
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English
β 395 KB
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The immunosuppressants FKSO6 and rapamycin bind to the same immunophilin, FKS06 binding protein (FKBP), and inhibit distinct signal transduction pathways in T lymphocytes. A nonnatural immunophilin ligand, S06BD, which contains only the common structural elements of FKSO6 and rapamycin, was synthesi