𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

✍ Scribed by Baumli, Sonja; Lolli, Graziano; Lowe, Edward D; Troiani, Sonia; Rusconi, Luisa; Bullock, Alex N; Debreczeni, Judit É; Knapp, Stefan; Johnson, Louise N

Book ID
109849556
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
671 KB
Volume
27
Category
Article
ISSN
0261-4189

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Catalytic activity of Cdk9 is required f
Catalytic activity of Cdk9 is required for nuclear co-localization of the Cdk9/cyclin T1 (P-TEFb) complex
✍ Giuliana Napolitano; Barbara Majello; Luigi Lania 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB 👁 1 views

## Abstract Cdk9 and its binding partner cyclin T1 comprise the positive elongation factor b (P‐TEFb). P‐TEFb phosphorylates the RNA polymerase II carboxyl‐terminal‐domain (CTD) allowing efficient transcription elongation. Recent studies showed that Cdk9 is a predominant nuclear protein, and here w

T-loop phosphorylated Cdk9 localizes to
T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes
✍ Eugene C. Dow; Hongbing Liu; Andrew P. Rice 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 560 KB

## Abstract P‐TEFb functions to induce the elongation step of RNA polymerase II transcription by phosphorylating the carboxyl‐terminal domain of the largest subunit of RNA polymerase II. Core P‐TEFb is comprised of Cdk9 and a cyclin regulatory subunit, with Cyclin T1 being the predominant Cdk9‐asso