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The structure of NoRC-associated RNA is crucial for targeting the chromatin remodelling complex NoRC to the nucleolus

✍ Scribed by Mayer, Christine; Neubert, Melanie; Grummt, Ingrid


Book ID
109850037
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
872 KB
Volume
9
Category
Article
ISSN
1469-221X

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## Abstract Many mammalian SWI/SNF complexes use Brahma‐related gene 1 (Brg1) as a catalytic subunit to remodel nucleosomes for transcription regulation. In several mesenchymal cells and tissues, expression of a defective Brg1 protein negates the normal activity of the SWI/SNF complex and delays or