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The Structure of Diastereomeric Oxaprotiline Metabolites. An NMR Study

✍ Scribed by Tammo Winkler; Walter Dieterle; Paul Hung; Grety Rihs; Hans-Peter Kriemler

Publisher
John Wiley and Sons
Year
1984
Tongue
German
Weight
297 KB
Volume
67
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The structure of phenolic metabolites of oxaprotiline, obtained from a study with rats and dogs, are assigned with NMR‐spectroscopic methods in combination with MS data and an X‐ray structure analysis of synthetic (9__R__*,2′S*)‐2‐chlorooxaprotiline, the metabolites are shown to be (9__R__*,2′R*)‐2‐hydroxy, 3‐hydroxy‐, and 2‐hydroxy‐3‐methoxyoxaprotiline, and (9__R__*,2′S*)‐2‐hydroxy‐, 3‐hydroxy‐, and 3‐hydroxy‐2‐methoxyoxaprotiline, as well as 2,6‐dihydroxyoxaprotiline.

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