The structure of daunomycin

✍ Scribed by R.H. Iwamoto; P. Lim; N.S. Bhacca

• Book ID: 104213827
• Publisher: Elsevier Science
• Year: 1968
• Tongue: French
• Weight: 202 KB
• Volume: 9
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)72359-8

✦ Synopsis

Daunomycin (l), .6, a bacterial metabolite, has shown interesting biological activity, especially as an antitumor agent. Mild acidic hydrolysis of daunomycin yields an aglycone, daunomycinone, 1, and the amino sugar daunosamine (2), 2. The structure of the sugar has been elucidated (2) and was confirmed by synthesis (3).

With the exception of the place-