The structure of adenylosuccinate lyase, an enzyme with dual activity in the de novo purine biosynthetic pathway

Structural and functional modularity of

Structural and functional modularity of proteins in the de novo purine biosynthetic pathway

✍ Hui Li; Walter Fast; Stephen J. Benkovic 📂 Article 📅 2009 🏛 Cold Spring Harbor Laboratory Press 🌐 English ⚖ 655 KB

## Abstract It is generally accepted that naturally existing functional domains can serve as building blocks for complex protein structures, and that novel functions can arise from assembly of different combinations of these functional domains. To inform our understanding of protein evolution and e