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The structure of a psychoactive agent: 7-chloro-3-hydroxy-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one (temazepam)

✍ Scribed by Gałdecki, Z. ;Główka, M. L.


Book ID
114527393
Publisher
International Union of Crystallography
Year
1980
Weight
574 KB
Volume
36
Category
Article
ISSN
0567-7408

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Synthesis of 7-chloro-1,3,-dihydro-3-hyd
✍ Jeremy G. Dain 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 217 KB 👁 1 views

Tema~epam-2-'~C, 7-Chloro-1,3-ihydro-3-hydroxy-1 -methyl-5-phenyl-2H-1,4-benzodiazepin-2-one--"C, was prepared in a f ive-step synthesis. Chl~roacetic-l-~~C acid was converted to the acid chloride with thionyl chloride. The acid chloride was allowed to react with 2-methylamino-5-chloro-benzophenone