Synthesis of 7-chloro-1,3,-dihydro-3-hyd
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Jeremy G. Dain
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Article
📅
1987
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John Wiley and Sons
🌐
French
⚖ 217 KB
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Tema~epam-2-'~C, 7-Chloro-1,3-ihydro-3-hydroxy-1 -methyl-5-phenyl-2H-1,4-benzodiazepin-2-one--"C, was prepared in a f ive-step synthesis. Chl~roacetic-l-~~C acid was converted to the acid chloride with thionyl chloride. The acid chloride was allowed to react with 2-methylamino-5-chloro-benzophenone