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The Structure of a Mixed GluR2 Ligand-binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-NS1209

✍ Scribed by Christina Kasper; Darryl S. Pickering; Osman Mirza; Lars Olsen; Anders S. Kristensen; Jeremy R. Greenwood; Tommy Liljefors; Arne Schousboe; Frank Wätjen; Michael Gajhede; Bent W. Sigurskjold; Jette S. Kastrup


Book ID
116662807
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
899 KB
Volume
357
Category
Article
ISSN
0022-2836

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The six-step synthesis of a chiral, pentadentate dihydrosalen ligand, carrying a mercaptomethyl group as additional binding site, is described. When this ligand was treated with nickel(I1) salts, a planar tetracoordinated nickel chelate was obtained, and not the expected pentacoordinated species. Th