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The Structure and Function of the Niemann–Pick C1 Protein

✍ Scribed by Yiannis A. Ioannou


Book ID
115639741
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
281 KB
Volume
71
Category
Article
ISSN
1096-7192

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Niemann-Pick C1-like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a cholesterol absorption inhibitor that effectively lowers plasma LDL-cholesterol in humans. However, human liver also expresses NPC1L1. Hepatic function of NPC1L1 was previ