The structural requirement of phosphatidylinositols as substrate of phosphatidylinositol 3-kinase

✍ Scribed by Ryuichi Shirai; Koji Morita; Asuka Nishikawa; Noriyuki Nakatsu; Yasuhisa Fukui; Naoko Morisaki; Yuichi Hashimoto

• Book ID: 104260802
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 321 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00004-0

✦ Synopsis

Synthetic distearate phosphatidylinositol (PI) was not phosphorylated by PI 3kinase. The fatty acids at glycerol sn-2 must be as short as octanoic acid or less to act as a substrate of PI 3-kinase.