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The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B †

✍ Scribed by Scapin, Giovanna; Patel, Sangita B.; Becker, Joseph W.; Wang, Qingping; Desponts, Caroline; Waddleton, Deena; Skorey, Kathryn; Cromlish, Wanda; Bayly, Christopher; Therien, Michel; Gauthier, Jacques Yves; Li, Chun Sing; Lau, Cheuk K.; Ramachandran, Chidambaram; Kennedy, Brian P.; Asante-Appiah, Ernest


Book ID
121300763
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
353 KB
Volume
42
Category
Article
ISSN
0006-2960

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## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we