The Structural Basis for the Selectivity of Benzotriazole Inhibitors of PTP1B †
✍ Scribed by Scapin, Giovanna; Patel, Sangita B.; Becker, Joseph W.; Wang, Qingping; Desponts, Caroline; Waddleton, Deena; Skorey, Kathryn; Cromlish, Wanda; Bayly, Christopher; Therien, Michel; Gauthier, Jacques Yves; Li, Chun Sing; Lau, Cheuk K.; Ramachandran, Chidambaram; Kennedy, Brian P.; Asante-Appiah, Ernest
- Book ID
- 121300763
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 353 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0006-2960
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## Abstract PTP1B is a protein tyrosine phosphatase involved in insulin and leptin signaling and is a primary mechanism for down‐regulating both the insulin and leptin receptor signaling pathways. Animals deficient in PTP1B have improved glucose regulation and lipid profiles and are resistant to we