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The Structural Basis for Docking in Modular Polyketide Biosynthesis

✍ Scribed by Kira J. Weissman


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
814 KB
Volume
7
Category
Article
ISSN
1439-4227

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## Abstract __To understand the structural basis for bisphosphonate therapy of bone diseases, we solved the crystal structures of human farnesyl pyrophosphate synthase (FPPS) in its unliganded state, in complex with the nitrogen‐containing bisphosphonate (N‐BP) drugs zoledronate, pamidronate, alend