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The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity

โœ Scribed by Michael B Yaffe; Katrin Rittinger; Stefano Volinia; Paul R Caron; Alastair Aitken; Henrik Leffers; Steven J Gamblin; Stephen J Smerdon; Lewis C Cantley


Book ID
117267431
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
322 KB
Volume
91
Category
Article
ISSN
0092-8674

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โœ John S. McMurray ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 451 KB

## Abstract Signal transducer and activator of transcription 3 (Stat3) is constitutively active in a number of cancers where it participates in aberrant transcription of prosurvival, cell cycling, and angiogenesis genes. Since Stat3 initiates its signaling activity through binding of its SH2 domain