## Abstract The condensation of 5‐methyl‐thiophen‐2‐aldehyde with dimethyl succinate in the presence of potassium t‐butoxide or sodium hydride gave predominantly (E)‐3‐methoxy‐carbonyl‐4‐(5′‐methyl‐2′‐thienyl)‐but‐3‐enoic acid **1a**, whose configuration is proved by cyclisation with sodium acetate
The STOBBE condensation. X. The cyclisation of (E)-3-methoxycarbonyl-4-(5′-methyl-2′-furyl)-but-3-enoic acid, and (E)−3-methoxycarbonyl-4-(2′-furyl)-pent-3-enoic acid, to Benzofuran Derivatives
✍ Scribed by Mrs. Dr. S. M. Abdel-Wahhab; Dr. N. R. El-Rayyes
- Book ID
- 105351962
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 392 KB
- Volume
- 314
- Category
- Article
- ISSN
- 1615-4150
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The title acid, a component of microsclerodermins of marine sponge origin having five consecutive stereogenic centers, was efficiently synthesized as its protected form 1 from the alcohol 5 utilizing the stereoselective addition of anisole to the acetylenic triple bond and the anti-aldol reaction as