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The stimulus-secretion coupling of amino acid-induced insulin release: insulinotropic action of branched-chain amino acids at physiological concentrations of glucose and glutamine

✍ Scribed by ABDULLAH SENER; WILLY J. MALAISSE

Book ID
114726168
Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
517 KB
Volume
11
Category
Article
ISSN
0014-2972

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The stimulus-secretion coupling of amino
The stimulus-secretion coupling of amino acid-induced insulin release
✍ Michael Welsh; Abdullah Sener; Francine Malaisse-Lagae; Willy J. Malaisse πŸ“‚ Article πŸ“… 1984 πŸ› Springer 🌐 English βš– 345 KB

Aminooxyacetate, an inhibitor of cytosolic transamination reactions, inhibited insulin release evoked by either 2-ketoisocaproate or L-leucine in rat pancreatic islets incubated in the presence of L-glutamine or L-asparagine. As a rule, aminooxyacetate also inhibited the oxidation of these nutrient