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The stimulation of human synovial fibroblast plasminogen activator activity Involvement of cyclic AMP and cyclooxygenase products

✍ Scribed by John A. Hamilton; Tali Leizer; Suzanne R. Lingelbach

Book ID
119120316
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
629 KB
Volume
886
Category
Article
ISSN
0167-4889

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Stimulation of the plasminogen activator
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## Abstract Nonrheumatoid human synovial fibroblasts in culture, while having low basal plasminogen activator levels, were stimulated to produce much more of this protease activity by low concentrations of a series of retinoids. The most potent retinoid tested, all‐trans retinoic acid, was active o

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## Abstract Human synovial fibroblasts in culture have been shown to have low plasminogen activator (PA) activity; however, conditioned medium from concanavalin A‐stimulated peripheral blood mononuclear cells (c‐MCCM) stimulates the cellular levels of this protease. The present study shows that low