The Star-Allele Nomenclature: Retooling for Translational Genomics
β Scribed by Robarge, J D; Li, L; Desta, Z; Nguyen, A; Flockhart, D A
- Book ID
- 110020141
- Publisher
- Nature Publishing Group
- Year
- 2007
- Tongue
- English
- Weight
- 212 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0009-9236
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The classical view of what constitutes an "allele" has been challenged by recent findings of a great deal of human genetic variability, i.e., we can expect, on average, one variant site every 100-250 bases of our haploid genome. The haplotype is defined as "the patterns of co-occurrence of variant s
## Abstract Studying the role of rare alleles in common disease has been prevented by the impractical task of determining the DNA sequence of large numbers of individuals. Nextβgeneration DNA sequencing technologies are being developed that will make it possible for genetic studies of common diseas