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The Stabilizing Effect of Moisture on the Solid-State Degradation of Gabapentin

✍ Scribed by Zhixin Zong; Salil D. Desai; Aditya M. Kaushal; Dewey H. Barich; Hong-Shian Huang; Eric J. Munson; Raj Suryanarayanan; Lee E. Kirsch

Book ID
111768382
Publisher
Springer US
Year
2011
Tongue
English
Weight
207 KB
Volume
12
Category
Article
ISSN
1530-9932

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## Purpose: To investigate the effect of plasticizers on the stability of protein formulations in the solid state and to apply these results to a study of mechanisms of protein stabilization by sugars in the solid sate. ## Methods: The igg1 antibody was formulated with either sucrose or trehalose