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The stabilization mechanism of mutant-type p53 by impaired ubiquitination: the loss of wild-type p53 function and the hsp90 association

✍ Scribed by Nagata, Yoichi; Anan, Tadashi; Yoshida, Tetsuo; Mizukami, Tamio; Taya, Yoichi; Fujiwara, Toshiyoshi; Kato, Hirohisa; Saya, Hideyuki; Nakao, Mitsuyoshi


Book ID
110062372
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
573 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract The E6 and E7 proteins of human papillomaviruses (HPV) play a crucial role in the pathogenesis of malignant tumors. E6 protein of high‐risk mucosal papillomaviruses targets a number of proteins for proteosomal degradation through complex formation with ubiquitin ligase E6AP. These prote