The stability of triplex DNA is affected by the stability of the underlying duplex
β Scribed by David A. Rusling; Phillip A. Rachwal; Tom Brown; Keith R. Fox
- Book ID
- 108074482
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 533 KB
- Volume
- 145
- Category
- Article
- ISSN
- 0301-4622
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## Abstract The unwinding free energy of 128 DNA octamers was correlated with the sum of interaction energies among DNA bases and their solvation energies. The former energies were determined by using the recently developed density functional theory procedure augmented by London dispersion energy (
## Abstract The triplex form of DNA is of interest because of a possible biological role as well as the potential therapeutic use of this structure. In this paper the stabilizing effects of two intercalating drugs, ethidium and the quinoxaline derivative 9βOHβB220, on DNA triplexes have been studie