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The stability of proton T2 effects of oxygen-17 water in experimental cerebral ischemia

✍ Scribed by A. L. Hopkins; W. D. Lust; E. M. Haacke; P. Wielopolski; R. G. Barr; C. B. Bratton

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
530 KB
Volume
22
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The gerbil model of unilateral cerebral ischemia has been used to test the temporal and spatial stability of the MRI T~2~ effects of oxygen‐17 water. Following unilateral carotid ligation, symptomatic animals were given a single large intraperitoneal injection of H~2~ ^17^O and the distribution and stability of the brain T~2~ effects were followed with a spin‐echo sequence. In contrast to the ischemic areas, the perfused tissue shows a marked and prolonged loss in intensity with little evidence of diffusion of the T~2~ effect of ^17^O into the ischemic tissue. © 1991 Academic Press, Inc.

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