The Stability of Digitalis Potency as Drug**Scientific Section, A. Ph. A., Dallas meeting, 1936.,11Research Laboratories of Parke, Davis & Company, Detroit, Michigan.

✍ Scribed by Rowe, L.W. ;Pfeifle, H.W.

• Publisher: Elsevier
• Year: 1936
• Weight: 264 KB
• Volume: 25
• Category: Article
• ISSN: 0898-140X
• DOI: 10.1002/jps.3080251006

✦ Synopsis

The blood pressure and respiratory effects produced by faradization of the sciatic nerve of the dog (2 experiments) under ether anesthesia were obliterated by a sling of pinacolone. After washing with normal salt solution, nerve conductivity was restored to normal. In a rabbit's cornea (1:500) pinacolone produced hyperemia of the conjunctiva and chemosis. No perceptible local anesthetic action was observed.

DISCUSSION.

The removal of a molecule of water from tetramethylene ethylene glycol with the formation of pinacolone destroys the hypnotic properties of the former and increases its toxicity. The major pharmacologic response elicited by pinacolone is that of reducing the blood pressure, which persists after massive doses of ergotamine and decerebration. The authors attribute the depressor response to vasodilation and cardiac depression.