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The stability of 2-acetoxy-4-trifluoromethylbenzoic acid (triflusal) in micellar pseudophase

✍ Scribed by M. Ferrit; C. Del Valle; M. López; R. Luque; F. Martínez

Book ID
102397974
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
136 KB
Volume
93
Category
Article
ISSN
0022-3549

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✦ Synopsis

The new platelet antiaggregant Triflusal or 2-acetoxy-4-trifluoromethylbenzoic acid presents a structural analogy to acetylsalicylic acid (ASA). Alkaline hydrolysis of triflusal was studied in the presence and absence of cationic micelles of N-cetyl-N-ethyl-N,N-dimethylammonium bromide (CDEABr) at different KOH concentrations and different temperatures (25, 30, and 378C) using a spectrophotometric method. The influence of potassium bromide concentration upon alkaline hydrolysis at 258C is also discussed. At constant [KOH] pseudofirst-rate constant (k obs ) decreased with increasing [CDEABr] at concentrations greater than the CMC and also decreased with increasing [KBr] at constant [KOH] and [CDEABr]. To explain the effect of cationic micelles of CDEABr upon alkaline hydrolysis, the pseudophase ion exchange model was used. The values of the micellar properties such as the critical micelle concentration, the degree of micellar ionization and the neutralized fraction of the head group obtained by conductivity measurements were determined previously.

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Binding of a metabolite of triflusal (2-hydroxy-4-trifluoromethylbenzoic acid) to serum proteins in rat and man
✍ R. Mis; J. Ramis; L. Conte; J. Forn 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 456 KB

2-hydroxy-4-trifluoromethylbenzoic acid (HTB) is the main active metabolite of the platelet antiaggregant drug triflusal. Its binding to plasma proteins of rats and healthy volunteers in vitro and in vivo has been studied. Rats were given a single oral dose of 50 mg.kg-1 triflusal and the healthy vo