Spontaneous degradation of polypeptides
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Todd V. Brennan; Steven Clarke
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Article
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2008
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Cold Spring Harbor Laboratory Press
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English
β 723 KB
## Abstract We have investigated the spontaneous degradation of aspartate and asparagine residues via succinimide intermediates in model peptides in organic coβsolvents. We find that the rate of deamidation at asparagine residues is markedly reduced in solvents of low dielectric strength. Theoretic