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The Stability and Degradation Pathway of Recombinant Human Parathyroid Hormone: Deamidation of Asparaginyl Residue and Peptide Bond Cleavage at Aspartyl and Asparaginyl Residues

✍ Scribed by Yoshiaki Nabuchi; Eri Fujiwara; Hitoshi Kuboniwa; Yoshinori Asoh; Hidetoshi Ushio


Book ID
110309150
Publisher
Springer US
Year
1997
Tongue
English
Weight
466 KB
Volume
14
Category
Article
ISSN
0724-8741

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Spontaneous degradation of polypeptides
✍ Todd V. Brennan; Steven Clarke πŸ“‚ Article πŸ“… 2008 πŸ› Cold Spring Harbor Laboratory Press 🌐 English βš– 723 KB

## Abstract We have investigated the spontaneous degradation of aspartate and asparagine residues via succinimide intermediates in model peptides in organic co‐solvents. We find that the rate of deamidation at asparagine residues is markedly reduced in solvents of low dielectric strength. Theoretic