𝔖 Bobbio Scriptorium
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The speed of corneal epithelial wound healing

✍ Scribed by P.D. Dale; J.A. Sherratt; P.K. Maini

Book ID
103925645
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
380 KB
Volume
7
Category
Article
ISSN
0893-9659

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✦ Synopsis

We propose a reaction-diffusion model of the mechanisms involved in the healing of cornea1 surface wounds. The model focuses on the stimulus for increased mitotic and migratory activity, specifically the role of epidermal growth factor. We determine an analytic approximation for the speed of travelling wave solutions of the model and verify the result numerically. The predicted speed compares very well with experimentally measured healing rates.

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Though it has been claimed that mitotic activity is stimulated after injury (Jus6lius, '10; Arey, '36; Arey and Covode, '43) it is now generally assumed that the covering of small epithelial defects takes place by "migration" of the neighbouring cells into the defect, and not by mitosis. Much of the