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The spectrum of mutations in TP53 in laryngeal cancer patients from a high-incidence population shows similarities to many of the known mutational hotspots

✍ Scribed by Desiré Barnard; Karen Lehmann; Eileen G. Hoal; Paul D. van Helden; Thomas C. Victor


Book ID
114135617
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
178 KB
Volume
145
Category
Article
ISSN
0165-4608

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Ser-249TP53 mutation in tumour and plasm
✍ Katarzyna Szymańska; Olufunmilayo A. Lesi; Gregory D. Kirk; Omar Sam; Philippe T 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 240 KB

## Abstract Hepatocellular carcinoma (HCC) is frequent in areas of high exposure to aflatoxin and high prevalence of HBV infection, such as western Africa and south‐east China. A selective mutation in __TP53__ (AGG→AGT at codon 249, Arg→Ser) has been identified as a hotspot in HCCs from such areas,