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The spatial distribution of dividing and DNA-synthesizing cells in mouse epithelium

✍ Scribed by Cameron, Ivan L. ;Gosslee, David G. ;Pilgrim, Christoph

Publisher: Wiley (John Wiley & Sons)
Year: 1965
Tongue: English
Weight: 288 KB
Volume: 66
Category: Article
ISSN: 0095-9898
DOI: 10.1002/jcp.1030660315

No coin nor oath required. For personal study only.

✦ Synopsis

Cells of the germinal layer of mouse esophageal epithelium were used for quantitative assessment of the spatial distribution of proliferating cells. In tritiated thymidine autoradiographs the nonsynthesizing cells between synthesizing (or dividing) cells were counted, rather than counting the dividing cells in preestablished grid units. Dividing and DNA-synthesizing cells are almost random in spatial distribution, but there is an excess of labeled or dividing cells immediately adjacent to one another over what would be expected if the spatial distribution were random. Two possible explanations for the excess of adjacent proliferating cells are suggested: ( a ) direct cellular interaction or local humoral influences, and ( b ) phasing of adjacent cells which have a common line of descent.

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